This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hypothesis: Antioxidant vitamins will have a beneficial role in improving heart function in patients with AL amyloidosis and cardiac involvement. Rationale: Animal heart model studies ahve shown deleterious effects of AL amyloid fibrils to heart tissue related to increased oxidative stress. Experimental Design: A randomized double-blind, placebo controlled pilot trial evaluating the effects of antioxidants on cardiac function in patients with AL amyloidosis. Patients with AL amyloidosis will have baseline cardiac studies. Those with cardiac involvement will be randomized to receive either vitamin C and vitamin E or placebo for 12 weeks time. The primary endpoint to evaluate cardiac function will be change in BNP. Secondary endpoints will be changed echocardiogram and change in clinical status.
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