This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this clinical research proposal is to investigate in vivo adherence of bacterial colonizers on natural tooth surfaces in the early non-growth phase of biofilm formation. We will use the checkerboard DNA-DNA hybridization assay to characterize the early attachment of microbial species. In vivo pellicle will be sampled from healthy volunteers and gingivitis patients. We will evaluate the attachment effect of tooth surfaces coated with serum saliva mixtures and evaluate the attachment effect of pellicle formed in different environments of dentition. The goal is to further understand the mineral-protein interface of oral environment and establish parameters involved in colonization of the surface by periodontal pathogens and other less deleterious microbial species.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000533-38
Application #
7379537
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2005-12-01
Project End
2006-11-30
Budget Start
2005-12-01
Budget End
2006-11-30
Support Year
38
Fiscal Year
2006
Total Cost
$111,952
Indirect Cost
Name
Boston University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
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