This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.This study is a three site randomized, single-blind controlled clinical trial to determine the benefits and side effects of risk assessment in those subjects who are at risk for developing Alzheimer's disease (AD) determined by genotyping. In the first step of this study, spouses or proxies (powers of attorney or substitute decision makers) of known Alzheimer's disease patients will be contacted and with consent will be asked to complete permisssion to contact the adult sons and daughters of the patient. In the second step, the sons/daughters will be asked to answer questions about their medical history, their attitudes toward genetic testing and risk assessment for Alzheimer's disease, and their interest in going on to the next step of the study where they could be offered risk assessment and counseling.Subjects will be carefully screened for appropriateness of being given genetic risk factor information. The psychometrician administering the testing wil be blinded to the subjects assignment in the Control or Study Arm. All subjects will be seen and called for follow-up for 12 months after disclosure of risk information. Frequent communication and proactive contact with study subjects will serve as safety monitoring during the study.We believe that providing education and risk assessment to adult offspring of AD patients will not increase anxiety levels among offspring. We also believe AD knowledge among offspring will improve. Boston University School of Medicine is the primary study site and data coordinating center, with Cornell Medical Center and Case Western Reserve University as collaborating sites.
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