The purpose of this study is to better understand how insulin affects protein metabolism in humans.
The specific aims are to determine the effect of intraarterial infusion of insulin on fractional synthesis rate of myosin and mixed muscle proteins in normal subjects and Type I diabetic patients, determine dose-related effect of insulin on protein dynamics, and to determine the validity of using Apo B as a marker of AA-tRNA label in liver in the fasted state during insulin infusion with or without amino acid replacement.

Project Start
1999-12-01
Project End
2000-11-30
Budget Start
Budget End
Support Year
29
Fiscal Year
2000
Total Cost
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
City
Rochester
State
MN
Country
United States
Zip Code
55905
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