The overall goal of the General Clinical Research Center (GCRC) at Dallas is to provide an optimal setting for clinical investigation which will lead to improved understanding of the disease process, allow better methods of diagnosis and treatment, foster interdisciplinary collaboration, and offer training in clinical investigation. Major activities of the GCRC include: Development of a safe and effective treatment of postmenopausal osteoporosis with intermittent slow-release sodium fluoride, based on a randomized trial, and incorporating a new reflection ultrasound device to assess bone quality; determination of the importance of calcitriol excess or sensitivity in nephrolithiasis due to absorptive hypercalciuria and in idiopathic osteoporosis and evaluation of treatment with a new slow-release neutral potassium phosphate (UroPhos-K); examination of the causes and management of primary hypercholesterolemia (elevated low density lipoproteins) and hypoalphalipoproteinemia (reduced high density lipoproteins); evaluation of erythrocyte galactitol accumulation as a surrogate for the direct measurement of erythrocyte aldose reductase and ascertainment of whether erythrocyte galactitol levels may predict high susceptibility to diabetic complications; determination of the safety and efficacy of anti-ICAM-1 (anti-adhesion molecule antibodies) in the treatment of rheumatoid arthritis; performance of a clinical trial of ursodeoxycholic acid and methotrexate in the treatment of patients with primary biliary cirrhosis; delineation of the regulation of cytolytic lymphocytes, which are involved in pulmonary immune defense and tissue injury, by pulmonary macrophages, and utilization of exercise testing, biochemical measurements and 31-phosphorus magnetic resonance spectroscopy to elucidate and intervene in disorders of muscle energy metabolism.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000633-23
Application #
2281305
Study Section
General Clinical Research Centers Committee (CLR)
Project Start
1978-12-01
Project End
1998-11-30
Budget Start
1994-12-01
Budget End
1995-11-30
Support Year
23
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75390
Gregg, L Parker; Tio, Maria Clarissa; Li, Xilong et al. (2018) Association of Monocyte Chemoattractant Protein-1 with Death and Atherosclerotic Events in Chronic Kidney Disease. Am J Nephrol 47:395-405
Askie, Lisa M; Darlow, Brian A; Finer, Neil et al. (2018) Association Between Oxygen Saturation Targeting and Death or Disability in Extremely Preterm Infants in the Neonatal Oxygenation Prospective Meta-analysis Collaboration. JAMA 319:2190-2201
Srinivasan, Lakshmi; Page, Grier; Kirpalani, Haresh et al. (2017) Genome-wide association study of sepsis in extremely premature infants. Arch Dis Child Fetal Neonatal Ed 102:F439-F445
Denson, Lee A; McDonald, Scott A; Das, Abhik et al. (2017) Early Elevation in Interleukin-6 is Associated with Reduced Growth in Extremely Low Birth Weight Infants. Am J Perinatol 34:240-247
James, Jennifer; Munson, David; DeMauro, Sara B et al. (2017) Outcomes of Preterm Infants following Discussions about Withdrawal or Withholding of Life Support. J Pediatr 190:118-123.e4
Younge, Noelle; Goldstein, Ricki F; Bann, Carla M et al. (2017) Survival and Neurodevelopmental Outcomes among Periviable Infants. N Engl J Med 376:617-628
Archer, Stephanie Wilson; Carlo, Waldemar A; Truog, William E et al. (2016) Improving publication rates in a collaborative clinical trials research network. Semin Perinatol 40:410-417
Sakhaee, Khashayar; Poindexter, John; Aguirre, Crystal (2016) The effects of bariatric surgery on bone and nephrolithiasis. Bone 84:1-8
Phelps, Dale L; Ward, Robert M; Williams, Rick L et al. (2016) Safety and pharmacokinetics of multiple dose myo-inositol in preterm infants. Pediatr Res 80:209-17
Foglia, Elizabeth E; Nolen, Tracy L; DeMauro, Sara B et al. (2015) Short-term Outcomes of Infants Enrolled in Randomized Clinical Trials vs Those Eligible but Not Enrolled. JAMA 313:2377-9

Showing the most recent 10 out of 693 publications