This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Highly Active Anti-Retroviral Therapies (HAART) that include HIV-1 protease inhibitors (PI) have greatly reduced HIV related mortality rates. However, many of these patients develop lipodystrophy, characterized by redistribution of body fat and insulin resistance. Hypertriglyceridemia and impaired glucose tolerance has been noted in 5- to 70% of patients treated with PI containing regimens. Low leptin levels have also been reported in some of these patients with selective loss of subcutaneous adipose tissue. We have recently demonstrated the efficacy of leptin replacement therapy in non HIV-infected patients with other genetic and acquired lipodystrophies. The purpose of this study is to investigate the safety and efficacy of leptin therapy in patients with HAART associated lipodystrophy.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000633-34
Application #
7377620
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2006-04-01
Project End
2007-03-31
Budget Start
2006-04-01
Budget End
2007-03-31
Support Year
34
Fiscal Year
2006
Total Cost
$81,681
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
800771545
City
Dallas
State
TX
Country
United States
Zip Code
75390
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