This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The current standard of care in acetaminophen overdose is to check a 4-hour acetaminophen level to determine if there is a potential for hepatotoxicity and thus a need for the treatment with N-acetyl cysteine. However, there is currently no standard for serum acetaminophen levels drawn before this 4-hour time mark. This study intends to explore the correlation of serum acetaminophen levels drawn 2-3 hours post-ingestion to the standard 4-hour levels. Patients will have a serum level drawn 2-3 hours post-ingestion and will also have the standard 4-hour level drawn to guide therapy. An arbitrary cut off value of 100mcg/ml will be used to compare groups. If patients have a serum acetaminophen less than 100mcg/ml then it is likely they will not cross the toxicity levels at 4 hours and thus would not need another level drawn at 4 hours, but could instead be dispositioned earlier. The study instends to determine if this cut off value of 100mcg/ml at 2-3 hours is a reliable predictor of low risk for hepatotoxicity as compared to the 4-hour leve
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