This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Low-grade systemic inflammation, manifested by increased plasma concentration of hs-CRP, precedes and predicts the development of cardiovascular disease. Plasma hs-CRP is closely related to both obesity and insulin resistance. However, the relative mechanistic role of obesity and insulin resistance is still controversial. In addition, no human studies have directly related plasma concentration of hs-CRP to adipocytokines production, such as IL-6 and TNF-alpha. The study investigators have recently reported that low-grade systemic inflammation can be observed even in absence ofobesity in persons of Asian Indian descent (originating from the Indian subcontinent). Therefore, the overall goal of this project is to test the hypothesis that in the presence of insulin resistance, increased production of cytokines from adipose tissue accounts for elevated hs-CRP and low grade systemic inflammation independent of obesity in humans.
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