Bay Y5959 Intravenous Infusion in Patients with Nyha Class III & IV Chf

Abstract

BAY y5959 is a new class of positive inotropic agent, structurally similar to the dihydropyridine calcium channel blockers. It is believed to work as a calcium agonist and has been associated with increased dP/dT in animal models and humans with heart failure. The current study aims to better characterize the safety, pharmacokinetics, and pharmacodynamics in patients with advanced CHF.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Center for Research Resources (NCRR)
• Type: General Clinical Research Centers Program (M01)
• Project #: 5M01RR000645-27
• Application #: 2786935
• Budget Start: 1997-10-01
• Budget End: 1998-09-30
• Support Year: 27
• Fiscal Year: 1998

Institution

• Name: Columbia University (N.Y.)
• DUNS #: 167204994
• City: New York
• State: NY
• Country: United States
• Zip Code: 10032

Publications

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Buckley, Jessie P; Engel, Stephanie M; Braun, Joseph M et al. (2016) Prenatal Phthalate Exposures and Body Mass Index Among 4- to 7-Year-old Children: A Pooled Analysis. Epidemiology 27:449-58

Leung, Vivien; Chiu, Ya-Lin; Kotler, Donald P et al. (2016) Effect of Recombinant Human Growth Hormone and Rosiglitazone for HIV-Associated Abdominal Fat Accumulation on Adiponectin and other Markers of Inflammation. HIV Clin Trials 17:55-62

Rosenbaum, Michael; Leibel, Rudolph L (2016) Models of energy homeostasis in response to maintenance of reduced body weight. Obesity (Silver Spring) 24:1620-9

Garyu, Justin W; Meffre, Eric; Cotsapas, Chris et al. (2016) Progress and challenges for treating Type 1 diabetes. J Autoimmun 71:1-9

Widen, Elizabeth M; Whyatt, Robin M; Hoepner, Lori A et al. (2016) Gestational weight gain and obesity, adiposity and body size in African-American and Dominican children in the Bronx and Northern Manhattan. Matern Child Nutr 12:918-28

Maresca, Michelle M; Hoepner, Lori A; Hassoun, Abeer et al. (2016) Prenatal Exposure to Phthalates and Childhood Body Size in an Urban Cohort. Environ Health Perspect 124:514-20

Tooley, James E; Vudattu, Nalini; Choi, Jinmyung et al. (2016) Changes in T-cell subsets identify responders to FcR-nonbinding anti-CD3 mAb (teplizumab) in patients with type 1 diabetes. Eur J Immunol 46:230-41

Branis, Natalia M; Etesami, Marjan; Walker, Ryan W et al. (2015) Effect of a 1-week, eucaloric, moderately high-fat diet on peripheral insulin sensitivity in healthy premenopausal women. BMJ Open Diabetes Res Care 3:e000100