This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Osteoporosis, skeletal pain, and fractures are frequent sequelae of cystic fibrosis (CF). The pathogenesis of bone disease in individuals with CF is complex, resulting both from processes that decrease bone formation and that increase bone resorption. Bone turnover in adults with CF has been shown to be abnormal with increased bone resorption yet normal bone formation. NO study as comprehensively assessed vitamin D metabolism in young children with CF.This study will compare children with CF to their unaffected siblings. Siblings were chosen as the controls in order to provide a comparison group for bone turnover measures and densitometric measurements and also to explore if there are effects of heterozygous CF transmembrane receptor mutations on bone mineral accrual. Assessment of bone mass and bone metabolism in prepubertal children with CF will allow determination of the role of these factors in the development of osteoporosis in these individuals. This will enable development of rational management and prophylactic interventions and therapies.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000750-36
Application #
7717503
Study Section
Special Emphasis Panel (ZRR1-CR-8 (01))
Project Start
2007-12-01
Project End
2008-05-31
Budget Start
2007-12-01
Budget End
2008-05-31
Support Year
36
Fiscal Year
2008
Total Cost
$58
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
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