Determine whether the intitial use of two non-nucleoside reverse transcriptase inhibitors (NRTIs) plus Nelfinavir followed by a different two NRTIs plus Efavirenz is superior to the initial use of two NRTIs plus Efavirenz followed by a different two NRTIs plus Nelfinavir. Determine whether initial use of two NRTIs plus Nelfinavir plus Efavirenz is superior to either of the two consecutive 3-drug regimens, and determine whether 3TC/ZDV followed by ddI + d4T is superior to ddI + d4T followed by 3TC/ZDV when these NRTI combinations are taken with Nelvinavir or Efavirenz.

Project Start
1999-12-01
Project End
2000-11-30
Budget Start
Budget End
Support Year
26
Fiscal Year
2000
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Type
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Grams, Morgan E; Sang, Yingying; Ballew, Shoshana H et al. (2018) Predicting timing of clinical outcomes in patients with chronic kidney disease and severely decreased glomerular filtration rate. Kidney Int 93:1442-1451
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