This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Designed to evaluate patients with unusual forms of in vivo insulin resistance. The underlying pathophysiology will be defined by evaluating endogenous insulin secretion, searching for the presence of hormonal insulin action and immune insulin antagonists, and examining peripheral insulin action in detail.
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