Abstract

The Clinical Research Center will permit clinical investigation in such areas as: 1) Evaluation of new drugs in petit mal epilepsy; 2) Regulation of gonadotropin and growth hormone levels; 3) Factors influencing iron absorption and transferrin kinetics; 4) Catecholamine metabolism in pheochromocytoma and renal failure; 5) Effects of angiotensin and analogues; 6) Evaluation and therapy of hypertension; 7) Classification of patients with diabetes mellitus; 8) Evaluation of polymorphonuclear leukocyte function in patients with recurrent infections and/or diabetes mellitus; 9) Examination of circulating immune complexes in systemic lupus erythematosus; 10) Regulation of plasma and urine levels of cyclic AMP and cyclic GMP and their utilization in diagnosis; 11) Therapy of hyperprolactenemia; 12) Evaluation of metabolic parameters in obesity and alterations with weight loss; 13) Evaluation and classification of inborn errors of metabolism. In addition the Clinical Research Center will permit faculty, fellows, house staff and students from many departments and disciplines to interact, collaborate, share ideas, and further promote investigation and teaching at this institution.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
2M01RR000847-18
Application #
3090133
Study Section
General Clinical Research Centers Committee (CLR)
Project Start
1985-12-01
Project End
1995-11-30
Budget Start
1991-01-14
Budget End
1991-11-30
Support Year
18
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
University of Virginia
Department
Type
Schools of Medicine
DUNS #
001910777
City
Charlottesville
State
VA
Country
United States
Zip Code
22904

  Publications

Campbell, Garland A; Patrie, James T; Gaylinn, Bruce D et al. (2018) Oral ghrelin receptor agonist MK-0677 increases serum insulin-like growth factor 1 in hemodialysis patients: a randomized blinded study. Nephrol Dial Transplant 33:523-530
Malin, Steven K; Rynders, Corey A; Weltman, Judy Y et al. (2016) Endothelial function following glucose ingestion in adults with prediabetes: Role of exercise intensity. Obesity (Silver Spring) 24:1515-21
Rynders, Corey A; Weltman, Judy Y; Malin, Steven K et al. (2016) Comparing Simple Insulin Sensitivity Indices to the Oral Minimal Model Postexercise. Med Sci Sports Exerc 48:66-72
Hu, Yinin; Kim, Helen; Blackwell, Christopher M et al. (2015) Long-term outcomes of helper peptide vaccination for metastatic melanoma. Ann Surg 262:456-64; discussion 462-4
Marozkina, Nadzeya V; Wang, Xin-Qun; Stsiapura, Vitali et al. (2015) Phenotype of asthmatics with increased airway S-nitrosoglutathione reductase activity. Eur Respir J 45:87-97
Nass, Ralf; Nikolayev, Alexander; Liu, Jianhua et al. (2015) The level of circulating octanoate does not predict ghrelin O-acyl transferase (GOAT)-mediated acylation of ghrelin during fasting. J Clin Endocrinol Metab 100:E110-3
Argo, Curtis K; Patrie, James T; Lackner, Carolin et al. (2015) Effects of n-3 fish oil on metabolic and histological parameters in NASH: a double-blind, randomized, placebo-controlled trial. J Hepatol 62:190-7
Chyun, Deborah A; Wackers, Frans J Th; Inzucchi, Silvio E et al. (2015) Autonomic dysfunction independently predicts poor cardiovascular outcomes in asymptomatic individuals with type 2 diabetes in the DIAD study. SAGE Open Med 3:2050312114568476
Hallmark, Rachel; Patrie, James T; Liu, Zhenqi et al. (2014) The effect of exercise intensity on endothelial function in physically inactive lean and obese adults. PLoS One 9:e85450
Nass, Ralf; Liu, Jianhua; Patrie, James et al. (2014) Four-hour infusion of hydrocortisone does not suppress the nocturnal increase of circulating acyl- or desacyl-ghrelin concentrations in healthy young adults. J Clin Endocrinol Metab 99:E1696-700

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