This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The prevalence of severe obesity is increasing at drastic rates in the United States. Research shows that surgery is the best method for rapid loss of significant extra weight. It is cost effective and safety is very good. While the health benefits of bariatric surgery have been proven (i.e. decreased insulin resistance, resolution of hypertension, improved cardiovascular health), and it is a frequently performed surgery, there exists no standard postoperative diet. While most patients are advised to follow a low-fat diet, little evidence supports this as the best option. Is a better postoperative diet available that could be used to help patients achieve better weight loss and health? We plan to randomize gastric bypass patients to receive teaching of either the standard, low-fat (control) diet or a higher-protein, lower-carbohydrate diet based on popular, and scientifically tested, diets. Therefore, if the post-gastric bypass diet teaching is changed to reflect a lower-carbohydrate, higher-protein diet, then patients should lose more weight and/or have better risk factor reduction.
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