This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.According to our observations, children and adults with SDB make high-pitched inspiratory sounds (between 3 and 10 kHz in frequency) during sleep. We believe that these sounds are due to narrowing of the upper airway during sleep and their occurrence is associated with SDB. As such, we propose a mechanistic hypothesis about the mechansim that produces high frequency sounds. Specifically, we hypothesize that people with obstructive sleep disordered breathing (OSDB) generate high-frequency sounds only when inspiratory effort is high as measured by esophageal pressure.We will study subjects with SDB. A standard polysomnographic sleep study with the addition of measurement of esophageal pressure will be done to all participants. We will record sounds with a microphone suspended over the bed. We will use analysis of variance and covariance regression models to analyze the data. Comparisons between and within the subjects will be done. The results of this study will allow us to determine the mechanism responsible for generation of high frequency sounds.
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