This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator.
The specific aim i s to determine is ischemic metabolites acutely sensitize muscle mechanoreflex control or RCVR. We hypothesize that in normal humans, ischemic metabolites, such as prostaglandins, acutely sensitize muscle mechanoreceptors during exercise resulting in augmented mechanoreceptor control of muscle sympathetic nerve activity (MSNA) and renal cortical vascular resistance (RCVR), and that this augmented mechanoreceptor control is exaggerated in patients with HF.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000865-33
Application #
7374822
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2005-12-01
Project End
2006-11-30
Budget Start
2005-12-01
Budget End
2006-11-30
Support Year
33
Fiscal Year
2006
Total Cost
$4,003
Indirect Cost
Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
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