This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator.
SPECIFIC AIMS :
Aim 1 : To identify the role of hereditary genetic polymorphisms in modulating levels of IL-6 production in healthy controls. Hypothesis 1: IL-6 promoter SNP that have been associated with increased levels of IL-6 in vitro testing systems will also be associated with increased levels of IL-6 in vivo.
Aim 2 : To evaluate the relationship between psychological measures, neuroendocrine activity and genetic polymorphisms in healthy controls. Hypothesis 2: Increased levels of IL-6 expression will be associated with greater levels of depression.
Aim 3 : To evaluate the relationship between body mass index, neuroendocrine activity and genetic polymorphisms in healthy controls. Hypothesis 3: Increased levels of IL-6 expression will be associated with greater levels of body mass index (BMI).
Aim 4 : To measure HSV8 expression in healthy controls. Hypothesis 7: Viruses which affect immune responsiveness by expressing viral cytokines may participate in immune dysregulation by modulating the cytokine network.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000865-33
Application #
7374872
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2005-12-01
Project End
2006-11-30
Budget Start
2005-12-01
Budget End
2006-11-30
Support Year
33
Fiscal Year
2006
Total Cost
$6,406
Indirect Cost
Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
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