Abstract

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to provide knowledge about the biological basis of cognitive impairments in MA abusers. The objective is to map abnormalities in brain function in MA abusers, as indexed by regional cerebral hemodynamic changes (activations), measured by fMRI. Activations will be related to performance on neuropsychological tests, to delineate the neurological basis for the behavioral effects of MA (and possible recovery) during 4-5 weeks of abstinence from the drug. We also plan to assess genetic factors implicated in this phenomenon. The information gleaned may help in designing therapies for MA dependence. Funded by the NIDA (DA-15179-01A1)

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000865-36
Application #
7951530
Study Section
Special Emphasis Panel (ZRR1-CR-4 (01))
Project Start
2009-04-01
Project End
2009-11-30
Budget Start
2009-04-01
Budget End
2009-11-30
Support Year
36
Fiscal Year
2009
Total Cost
$231,451
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Ellsworth, G B; Lensing, S Y; Ogilvie, C B et al. (2018) A delayed dose of quadrivalent human papillomavirus vaccine demonstrates immune memory in HIV-1-infected men. Papillomavirus Res 6:11-14
Goldman, Noreen; Glei, Dana A; Weinstein, Maxine (2018) Declining mental health among disadvantaged Americans. Proc Natl Acad Sci U S A 115:7290-7295
Dean, Andy C; Morales, Angelica M; Hellemann, Gerhard et al. (2018) Cognitive deficit in methamphetamine users relative to childhood academic performance: link to cortical thickness. Neuropsychopharmacology 43:1745-1752
Nersesian, Paula V; Han, Hae-Ra; Yenokyan, Gayane et al. (2018) Loneliness in middle age and biomarkers of systemic inflammation: Findings from Midlife in the United States. Soc Sci Med 209:174-181
Glei, Dana A; Goldman, Noreen; Ryff, Carol D et al. (2018) Physical Function in U.S. Older Adults Compared With Other Populations: A Multinational Study. J Aging Health :898264318759378
Stephan, Yannick; Sutin, Angelina R; Bayard, Sophie et al. (2018) Personality and sleep quality: Evidence from four prospective studies. Health Psychol 37:271-281
Green, Shulamite A; Hernandez, Leanna M; Bowman, Hilary C et al. (2018) Sensory over-responsivity and social cognition in ASD: Effects of aversive sensory stimuli and attentional modulation on neural responses to social cues. Dev Cogn Neurosci 29:127-139
Chung, Joon (2017) Social support, social strain, sleep quality, and actigraphic sleep characteristics: evidence from a national survey of US adults. Sleep Health 3:22-27
Glei, Dana A; Goldman, Noreen; Ryff, Carol D et al. (2017) Can we determine whether physical limitations are more prevalent in the US than in countries with comparable life expectancy? SSM Popul Health 3:808-813
Scherzer, Rebecca; Heymsfield, Steven B; Rimland, David et al. (2017) Association of serum albumin and aspartate transaminase with 5-year all-cause mortality in HIV/hepatitis C virus coinfection and HIV monoinfection. AIDS 31:71-79

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