Repeated administration of long-acting hallucinogens rapidly elicits tolerance to their psychological effects. N,N-Dimethyltryptamine (DMT) is a very short acting endogenous hallucinogen & drug of abuse, tolerance to which has never been demonstrated in humans. We will attempt to develop tolerance in a pilot group of three subjects by gradually increasing doses and frequency of administration of 4 consecutive doses, and then studying 12 experienced hallucinogen users using repeated placebo and repeated DMT on 2 separate days.

Project Start
Project End
Budget Start
Budget End
Support Year
19
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of New Mexico
Department
Type
DUNS #
829868723
City
Albuquerque
State
NM
Country
United States
Zip Code
87131
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