The Clinical research Center application detailed herein proposes a series of clinical investigations into the etiology, pathophysiology, diagnosis, and treatment of a variety of human disease states. Specific areas of investigation include, among others, the following: The characterization of the differential response to the cysteinyl leukotrienes in patients with bronchial asthma; an examination of the structure of the insulin receptor gene and its relationship to insulin action in vivo and in vitro in patients with different types of diabetes mellitus; an investigation of the role of serotonin in patients with eating disorders; an investigation into the relationship between insulin and the sympathetic nervous system in obesity-related hypertension; the characterization of the mechanisms of impaired thirst and renal sodium excretion in aging; an examination of the efficacy of diet and pharmacotherapy in reversing human coronary atherosclerosis; the early diagnosis and treatment of various prethrombotic states; an investigation of the role of renal amine formation in the pathogenesis of human hypertension; studies of the efficacy of new drugs to treat the complications of AIDS; studies of the mechanism of altered glucose metabolism in aging; studies to determine the efficacy of pharmacotherapy to treat patients with Alzheimer's disease and other memory disorders; an investigation to determine whether administration of fish oil mitigates the nephrotoxicity of cyclosporine in renal transplant patients; and an investigation of the optimal mechanisms for achieving successful balloon valvuloplasty of the aortic and mitral valves. The specific research proposals are detailed in this application.
Showing the most recent 10 out of 642 publications
