This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall purpose of this study is to expand upon the observation of impaired motor learning in DYT1 transgenic mice by evaluating patients with mutation in the DYT1 gene for deficits in motor learning. With this study, the intent is to deepen the understanding of the relationship between the adaptive neuronal mechanisms supporting procedural learning and the 'maladaption' observed in dystonia. Specifically, skill acquisition, motor consolidation, and 'off-line' learning will be examined, using dynamic adaptation and sequence learning paradigms.
Showing the most recent 10 out of 642 publications