To investigate the efficacy of r-metHuBDNF (25 and 150 ug/day) on survival, free from permeanent assisted ventilation (PAV), in subjects with ALS when administered by continuous intrathecal infusion for 18 months. Ventilation will be considered permeant when employed >22 hurs a day for >14 consecutive days and defined retrospectively as the beginning of that 14 day period.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR001066-23
Application #
6409607
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
1978-02-01
Project End
2002-11-30
Budget Start
Budget End
Support Year
23
Fiscal Year
2000
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
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