This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Classification of patients with PCOS relies on cumbersome laboratory and ultrasound evaluations. This study will examine the role of outpatient urine testing (full alpha subunit and c-peptide) compared with other endocrine abnormalities (detected with frequent blood testing, oral glucose tolerance tests) known to be associated with PCOS. The overall goal is to validate outpatient biochemical tests as a means of defining discrete pathophysiologic subtypes of PCOS patients precisely and accurately.
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