This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is designed to determine the effects of an intensive lifestyle modification program in patients with HIV and Metabolic Syndrome. A large waist circumference, high blood cholesterol levels, high blood pressure, and high insulin and glucose levels characterize Metabolic Syndrome. These metabolic abnormalities increase the risk of developing heart disease and/or diabetes. In HIV-infected patients it is known that use of highly active antiretroviral therapy is associated with similar metabolic abnormalities and Metabolic Syndrome has been seen in a sub-set of HIV-infected patients. Proven therapeutic strategies to reduce the risk of cardiovascular disease and diabetes in non-HIV infected patients have been identified. These strategies focus on diet, exercise, and lifestyle changes recommended from multiple national clinical guidelines. However, these strategies have yet to be tested in the treatment of HIV-infected patients with Metabolic Syndrome. In this study we would like to find out if the same benefit can be seen in patients with HIV and Metabolic Syndrome. The purpose of this study is to find out if a one-on-one counseling program teaching subjects with HIV and Metabolic Syndrome about healthy eating and exercise will help to improve their body composition, heart health, and lower their risk of developing diabetes and/or heart disease in comparison to subjects that do not receive the counseling. We plan on enrolling a total of 80 subjects in this study and the total duration is 12 months.
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