This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of this Phenotype-Genotype Project in Addictions and Mood Disorders is to understand the genetic bases for the brain circuitry alterations conferring susceptibility or resistance to stimulant dependence and depression. The initial phase of this project will characterize neuroimaging-based markers of these illnesses in multiple members of extended families so as to establish their familiality/heritability. A subsequent phase of this project will, once further funding is obtained, seek to identify the genetic bases of addiction and depression. To derive circuitry-based endophenotypes for addiction and depression, we will employ morphometric and functional magnetic resonance imaging (mMRI and fMRI). This study aims to delineate a set of psychiatric phenotypes and circuitry-based endophenotypes in 900 subjects. Once endophenotypic markers associated with these neuropsychiatric diseases have been characterized, we will then look to link genetic polymorphisms.
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