This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objective of this study is to compare predicted and measured resting energy expenditure (REe) using different methods. Study Aom #1: To compare resting energy expenditure in overweight and obese individuals determined by three methods: 1) prediction equation (Harris Benedict Equation (HBE)), 2) traditional indirect calorimetry (Vmax 29N) with measured respiratory quotient (RQ), and 3) handheld device (MedGemTM) with fixed RQ to determine REE.
Study Aim #2 : To assess participant preference for different methods of determining REE. In order to test the hypothesis that there is a significant difference in preference, we will have the participants rate 1) traditional indirect calorimetry (Vmax 29N) with measured RQ and 2) hand-held device (MedGemTM) with fixed RQ using a mouthpiece to determine preference.
Study Aim #3 : To compare body composition, specifically lean body mass, with REE.
Study Aim #4 : To describe the subject population relative to the metabolic syndrome and the associaton of different components of the metabolic syndrome with REE. The metabolic syndrome is defined when 3 or more of the following abnormalities related to weight are present: Waist circumference >102 cm (40in) in men and >88 (35 in) in women, triglycerides (TG) > 150 mg/dl, high-density lipoprotein (HDL) <40 mg/dl in men and <50 mg/dl in women, blood pressure >130/85 mm Hg (elevation of systolic and/or diastolic blood pressure), and/or fasting glucose >110 mg/dl.
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