This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The hypothesis of this study is to show that giving D4T to healthy HIV negative subjects will effect mitochondrial activity in the muscle bed thereby increasing intramyocellular lipid and decreasing insulin sensitivity.
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