This renewal proposal is requesting NIH support for an eight bed General Clinical Research Center at the Medical University of South Carolina. Major areas of study include: mineral metabolism and its regulation in health and diseases; platelet aggregation in diabetes mellitus; design and evaluation of neurotranshibitor drugs; prostaglandins and the control of renal water excretion; salt metabolism in children of normal and hypertensive parents; the adrenergic neuron as a storage and release site of propranolol in man; detection and characterization of connective tissue disease; the kallikrein-kinin system in renal function, hypertensive and other diseases; and the metabolism, pharmacokinetics and pharmacodynamics of propranolol stereoisomers in normal and hypertensive man. The proposed work is to be carried out in an environment which emphasizes interdisciplinary collaboration between basic biomedical scientists and clinical investigators. Analytical and synthetic chemistry and biochemistry are of central importance to the work in this General Clinical Research Center.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
2M01RR001070-15
Application #
3090242
Study Section
General Clinical Research Centers Committee (CLR)
Project Start
1977-03-01
Project End
1995-11-30
Budget Start
1991-01-15
Budget End
1991-11-30
Support Year
15
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Medical University of South Carolina
Department
Type
Schools of Medicine
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29425
Kelly, Clare B; Hookham, Michelle B; Yu, Jeremy Y et al. (2018) Subclinical First Trimester Renal Abnormalities Are Associated With Preeclampsia in Normoalbuminuric Women With Type 1 Diabetes. Diabetes Care 41:120-127
Putterman, Chaim; Pisetsky, David S; Petri, Michelle et al. (2018) The SLE-key test serological signature: new insights into the course of lupus. Rheumatology (Oxford) 57:1632-1640
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Kelly, Clare B; Hookham, Michelle B; Yu, Jeremy Y et al. (2018) Response to Comment on Kelly et al. Subclinical First Trimester Renal Abnormalities Are Associated With Preeclampsia in Normoalbuminuric Women With Type 1 Diabetes. Diabetes Care 2018;41:120-127. Diabetes Care 41:e102-e103
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Hollis, Bruce W; Wagner, Carol L (2016) Response to commentary by D Roth. Evid Based Med 21:120
Hollis, Bruce W; Wagner, Carol L; Howard, Cynthia R et al. (2015) Maternal Versus Infant Vitamin D Supplementation During Lactation: A Randomized Controlled Trial. Pediatrics 136:625-34

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