Paget's Disease of bone can be crippling in deformities, pain, and nerve entrapment. Bisphosphonates offer some degree of control of active osteolysis and thereby osteogenesis. They are poorly absorbed from the gastrointestinal tract. IV therapy has maintained responses for 6 months or longer. Thirty mg. infusions of APD(Palmidronate disodium) will be given intravenously for four hours on three successive days.

Project Start
Project End
Budget Start
Budget End
Support Year
16
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Medical University of South Carolina
Department
Type
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29425
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Kelly, Clare B; Hookham, Michelle B; Yu, Jeremy Y et al. (2018) Response to Comment on Kelly et al. Subclinical First Trimester Renal Abnormalities Are Associated With Preeclampsia in Normoalbuminuric Women With Type 1 Diabetes. Diabetes Care 2018;41:120-127. Diabetes Care 41:e102-e103
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Hollis, Bruce W; Wagner, Carol L; Howard, Cynthia R et al. (2015) Maternal Versus Infant Vitamin D Supplementation During Lactation: A Randomized Controlled Trial. Pediatrics 136:625-34

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