Prior study has provided data suggesting that interferon gamma 1b improves bone resorption, yielding an increse in bone marrow space; improves white cell super-oxide production, and reduces the trend toward progressive narrowing of the cranial nerve foramina. This study proposes to determine if interferon gamma 1b therapy combined with calcitriol can improve bone turnover, marrow function, and the size of cranial nerve foramina in severe osteopetrosis to a greater extent than calcitriol alone through a randomized, controlled, open-label trial.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
3M01RR001070-24S5
Application #
6411597
Study Section
Project Start
1999-12-01
Project End
2001-03-01
Budget Start
Budget End
Support Year
24
Fiscal Year
2001
Total Cost
Indirect Cost
Name
Medical University of South Carolina
Department
Type
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29425
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