This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The purpose of this study is to evaluate whether men and women respond differently to seeing items related to cocaine use or to remembering stressful events. Four groups of individuals will be recruited to participate in this study: men with cocaine dependence, women with cocaine dependence, men without cocaine dependence, and women without cocaine dependence. To be accepted into the research study, you must first be evaluated and the results of this evaluation must meet entrance requirements. The entire study involves several outpatient visits and two consecutive overnight stays in the hospital. On the first visit, you will be interviewed and asked to fill out questionnaires about your cocaine use history and psychological/psychiatric status. If you are female, you will be asked about the time of your last menstrual period. Subjects will have a physical examination and may have blood drawn (about a tablespoon) to check general health. Subjects breath will be tested for alcohol use, and a urine sample will also be collected to screen for cocaine and other drugs of abuse. Subjects must remain free of alcohol and other drugs for at least two days before being admitted to the hospital for the two consecutive overnight stays required by tests for this study. If lab results, self-report, or the clinical observations of study staff suggest use of alcohol or drugs within two days of a scheduled hospital admission, the admission will be at the discretion of study staff. Subjects may be asked to come in daily for urine drug screens and have breath checked for alcohol the five days prior to admission. Female admission to the hospital will also be determined by when the next menstrual period starts.
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