This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Fibromyalgia is characterized by chronic widespread pain and due to limited treatment outcomes, novel treatments are needed. Brain stimulation using surgically-implanted electrodes has been used extensively to control other forms of chronic intractable pain. However, these interventions are invasive and costly and are not likely to be considered for the treatment of fibromyalgia. Cortical stimulation can be performed non-invasively by repetitive transcranial magnetic stimulation (rTMS) and a few studies have shown that rTMS can decrease pain perception in healthy adults and patients with chronic pain. This study will conducted as a pilot study of TMS as a therapeutic intervention with an emphasis on African Americans with fibromyalgia (FM). This pilot study will help determine if it is feasible to screen, enroll, treat and follow-up African American FM subjects for a rTMS intervention over the course of one year.
A second aim i t to gather and summarize data that will be used to design a trial regarding modulation of pain, depression, function, and quality of life using TMS with an emphasis on African American FM patients. The data gathered will be summarized to provide estimates of standard deviations to be used to calculate sample size for a larger Phase III trial comparing TMS to a sham intervention.
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