This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Marijuana is the most commonly used illicit drug in the United States. Although the use of marijuana is widespread and the basic science research on cannabinoids is well developed, little research has focused on the clinical treatment of marijuana use disorders. One area of importance in the study of substance use disorders is relapse. In brief, cue reactivity is a construct measured in a laboratory procedure where an individual s subjective, behavioral, and physiological responses are assessed following exposure to drug-related environmental cues. This study proposes an innovative approach to investigate the effects of drug-related environmental cues and stress inmarijuana-dependent individuals using a clinical laboratory paradigm. The study design is experimental and the study population is 60 men or women who meet DSM-IV criteria for marijuana dependence. In addition to marijuana-specificenvironmental cues, the Trier Social Stress Task (TSST), a standardized psychological stress challenge which has been used extensively in research studies, will be used.
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