EXCEEDTHE SPACE PROVIDED. Continuation of the General Clinical Research Center for neonates, children and youth (PCRC) at the University of California, San Francisco (UCSF) and a satellite unit at Children's Hospital Oakland (CHO) is proposed in order to provide facilities for multidisciplinary intensive bedside and outpatient clinical investigation of human disease. Faculty members of the clinical and basic science departments of the School of Medicine at UCSF and CHO as well as the Schools of Nursing and Pharmacy will study diseases and treatment strategies which include most of the major fields of clinical investigation hi Pediatrics. The PCRC provides uniqueopportunities for the training of students, residents, post-doctoral fellows and junior faculty. We request new support for a 'Mentored Medical Student Research Program' as well as 'Clinical Research Feasibility Funds' to strengthen our training program. We request support for an inpatient/outpatient Center as well as a neonatal scatterbed unit at UCSF; a scatterbed unit and outpatient facility at CHO are proposed. The Center and Satellite units provide for the hospitalization of patients in a setting in which skilled intensive nursing care, the precise collection of blood and urine, as well as other special procedures can be carried out A Core Laboratory at UCSF and a satellite HLA-typingCore Laboratory at CHOare proposed. Support is requested for a biostatistics core, an informatics core, a dietician and a child psychologist to provide essential services for investigators and to train students and post-doctoral fellows. The proposed research program at UCSF includes over 80 protocols, and 52 principal investigators from departments including pediatrics, medicine, surgery, obstetrics, neurology, neurosurgery, radiology, radiation oncology, ophthalmology, and urology. Major research programs include molecular analysis of children with inheritable disease and/or malignancies; pathogenesis and treatment of children with primary immunodeficiency disorders; the use of novel agents such as '' I-metaiodobenzylguandine for the treatment of patients with advanced neuroblastoma; pathogenesis and treatment of Pediatric AIDS; magnetic resonance parameters as predictors of outcome hi neonates with CNS hypoxia; pathogenesis, early intervention and long term sequellae in childhood obesity and type I diabetes mellitus; intervention strategies in Sickle Cell Anemia and thalassemia; fetal surgery strategies for congenital diaphragmatic hernia; natural history of HPV infection hi cervical cancer. The PCRC supports multiinstitutional trials through the Children's Oncology Group, Pediatric AIDS Clinical Trials Group and Pediatric GI consortium.
Showing the most recent 10 out of 502 publications
