Troxacitabine is a cytotoxic L-enantiomer nucleoside analog which appears to inhibit DNA polymerases and act as a complete DNA chain terminator. Since it can inhibit DNA replication and repair, it is an attractive candidate for combination with agents such as cisplatin that cause DNA damage. This Phase I study of Troxacitabine in combination with cisplatin will determine the maximum tolerated dose of the combination.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR001346-21
Application #
6586884
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2001-12-01
Project End
2002-11-30
Budget Start
Budget End
Support Year
21
Fiscal Year
2002
Total Cost
Indirect Cost
Name
University of Texas Health Science Center San Antonio
Department
Type
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229
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