Phase I, dose-escalating, long-term AIDS Clinical Trial Group (ACTG) tolerance study of oral ganciclovir in HIV-infected infants, children and adolescents with asymptomatic CMV infection and low CD4 cell counts, and/or quiescent CMV disease. The study is designed to evaluate the pharmacokinetics and to determine pharmacokinetic parameters of the oral suspension of ganciclovir. Ganciclovir has been used intravenously for more than 10 years and is currently given to children intravenously for CMV disease. In a recent study, oral ganciclovir was safely given to adult AIDS patients and was shown to be useful in preventing or postponing CMV disease, but has never been given to children.

Project Start
1998-12-01
Project End
1999-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
17
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
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