A pilot study to determine what dose of DHEA is needed over an 8 week period to restore physiologic levels of this hormone, suppress markers of bone resorption, and increase markers of bone formation. Underweight patients with eating disorders have been found to have subnormal levels of DHEA, as well as severe osteopenia and/or osteoporosis. These patients have also been found to have both decreased bone formation and increased resorption. The study will examine if subnormal levels of the hormone are related to these bone abnormalities in bone formation and turnover. The investigators seek to obtain safety and efficacy data in this pilot study in order to design a subsequent longitudinal study which will more definitively evaluate the use of DHEA in these disorders.

Project Start
1998-12-01
Project End
1999-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
17
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
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