Abstract

The research proposed will investigate the relationship between Antisocial Personality Disorder (ASPD) and alcohol induced aggressive responding. The neurochemical mechanisms of alcohol's effects upon these behaviors under controlled laboratory conditions will be determined with a specific focus on the neurotransmitter serotonin.
Specific Aim 1. To determine the effect of tryptophan depletion and augmentation on aggressive responding in alcohol drinking subjects with Antisocial Personality Disorder (ASPD) and alcohol drinking non-ASPD controls. Hypothesis Related to Specific Aim 1: Alcohol drinking subjects with ASPD will show a greater increase in aggressive responding on the Point Subtraction Aggression Paradigm (PSAP) after tryptophan depletion than non-ASPD alcohol drinking subjects.
Specific Aim 2. To determine the effect of tryptophan depletion and augmentation on alcohol induced aggressive responding in subjects with ASPD and alcohol drinking controls. Hypotheses Related to Specific Aim 2: a. Within subjects, aggressive responding on the PSAP after the alcohol dose will be greater after tryptophan depletion than after tryptophan augmentation. b. Subjects with ASPD will show a greater increase in aggressive responding than non-ASPD subjects in the alcohol dose and tryptophan depletion condition.
Specific Aim 3. To measure serotonin function in ASPD subjects and controls using a neuroendocrine challenge with the 5-HT1B/1D agonist zolmitriptan. Hypothesis Related to Specific Aim 3: Alcohol drinking subjects with ASPD will have a significantly blunted growth hormone response to zolmitriptan neuroendocrine challenge compared matched alcohol drinking controls.
Specific Aim 4. To determine if the 5-HT1B/1D agonist zolmitriptan blocks alcohol induced aggressive responding in subjects with ASPD and matched controls. Hypotheses Related to Specific Aim 4: a. The 5-HT1B/1D agonist zolmitriptan will decrease alcohol induced aggression in all subjects. b. Subjects with ASPD will show the greatest decrease in alcohol induced aggression after zolmitriptan administration. c. The decrease in alcohol induced aggression will inversely correlate with the peak growth hormone response to zolmitriptan in subjects who have completed Aim III.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR002558-14
Application #
6121143
Study Section
Project Start
1998-12-01
Project End
1999-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
14
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Texas Health Science Center Houston
Department
Type
DUNS #
City
Houston
State
TX
Country
United States
Zip Code
77225

  Publications

Chappell, Cynthia L; Darkoh, Charles; Shimmin, Lawrence et al. (2016) Fecal Indole as a Biomarker of Susceptibility to Cryptosporidium Infection. Infect Immun 84:2299-306
Liao, George P; Harting, Matthew T; Hetz, Robert A et al. (2015) Autologous bone marrow mononuclear cells reduce therapeutic intensity for severe traumatic brain injury in children. Pediatr Crit Care Med 16:245-55
Arroyo-Ávila, Mariangelí; Santiago-Casas, Yesenia; McGwin Jr, Gerald et al. (2015) Clinical associations of anti-Smith antibodies in PROFILE: a multi-ethnic lupus cohort. Clin Rheumatol 34:1217-23
Chappell, Cynthia L; Okhuysen, Pablo C; Langer-Curry, Rebecca C et al. (2015) Cryptosporidium muris: infectivity and illness in healthy adult volunteers. Am J Trop Med Hyg 92:50-5
Reveille, John D (2014) An update on the contribution of the MHC to AS susceptibility. Clin Rheumatol 33:749-57
Bethi, Siddharth; Dasgupta, Abhijit; Weisman, Michael H et al. (2013) Functional limitations due to axial and peripheral joint impairments in patients with ankylosing spondylitis: are focused measures more informative? Arthritis Care Res (Hoboken) 65:607-14
Ward, Michael M; Learch, Thomas J; Gensler, Lianne S et al. (2013) Regional radiographic damage and functional limitations in patients with ankylosing spondylitis: differences in early and late disease. Arthritis Care Res (Hoboken) 65:257-65
Benjamin-Garner, Ruby; Stotts, Angela (2013) Impact of smoking exposure change on infant birth weight among a cohort of women in a prenatal smoking cessation study. Nicotine Tob Res 15:685-92
Ornstein, Tisha J; Max, Jeffrey E; Schachar, Russell et al. (2013) Response inhibition in children with and without ADHD after traumatic brain injury. J Neuropsychol 7:1-11
Murthy, Vijaya; Willis, Rohan; Romay-Penabad, Zurina et al. (2013) Value of isolated IgA anti-?2 -glycoprotein I positivity in the diagnosis of the antiphospholipid syndrome. Arthritis Rheum 65:3186-93

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