This is a clinical trial of antihypertensive pharmacologic treatment and, in a specific subset, cholesterol-lowering, in high-risk hypertensive patients. The purpose is to determine whether the incidence of coronary heart disease and myocardial infarction differs between diuretic treatment and three alternative antihypertensive pharmacologic treatments - a calcium antagonist, an ACE inhibitor, and an alpha adrenergic blocker. As of February 2000, we have enrolled 53 patients. Enrollment is closed and we are now in the follow-up period. Future plans are to monitor for cardiovascular events and maintain enrollees in the protocol. This year the PI hosted an appreciation dinner for study participants.

Project Start
1998-12-01
Project End
1999-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
14
Fiscal Year
1999
Total Cost
Indirect Cost
City
Houston
State
TX
Country
United States
Zip Code
77225
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