To compare the efficacy of lamivudine vs. placebo vs. lamivudine followed by the combination of intron A plus lamivudine in patients with chronic hepatitis B infection who are interferon alpha non-responders. There will be two primary efficacy variables: histological response (for comparison of the monotherapy regimes) and seroconversion rates (for the comparison of the placebo and combination regimes). Complete or partial normalization of serum alanine aminotransferase (ALT) and HBsAg seroconversion will be secondary markers of efficacy

Project Start
1997-12-01
Project End
1998-11-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
14
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Kentucky
Department
Type
DUNS #
832127323
City
Lexington
State
KY
Country
United States
Zip Code
40506
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