This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary hypothesis is that the aripiprazole-cocaine combinations will be well tolerated and no adverse effects will occur. Secondary hypotheses include: 1) intranasal cocaine will produce prototypical stimulant-like subjective effects (e.g., increased ratings Drug Liking); 2) aripiprazole will produce mild, transient side effects observed with antipsychotics (e.g., sedation, performance impairment); and 3) aripiprazole maintenance will attenuate the subjective effects of intranasal cocaine (i.e., shift the cocaine dose-response curve rightward). Cocaine abuse and dependence continue to be significant public health concerns. Despite intensive efforts by numerous research teams, an effective pharmacotherapy for cocaine dependence has yet to be identified. The purpose of the present line of research is to examine the efficacy of aripiprazole as a putative agonist pharmacotherapy for cocaine dependence. The present study will examine the safety and tolerability of cocaine-aripiprazole combinations in 12 volunteers with history of cocaine abuse or dependence. We predict that the cocaine-aripiprazole combinations will be safe and tolerable.
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| Ewen, Heidi H; Chahal, Jasleen K; Fenster, Emily S (2015) A portrait of resilience in caregiving. Res Gerontol Nurs 8:29-38 |
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