This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The objectives of this study is to describe the pharmacokinetics of levofloxacin 750mg in ambulatory obese volunteers and in hospitalized obese patients. The pharmacokinetics of a 750mg intravenous does of levofloxacin administered to severly obese volunteers will not differ significantly from that of obese, hospitalized medical patients. Determine the following pharmacokinetic parameters of levofloxacin in ovese individuals: Cmax, Tmax, area under the concentration-time curve (AUC), volume of distribution, elimination rate, serum half-life, and urine clearance. Investigate the correlation between levofloxacin volume of distribution and actual adipose mass as determined by the whole body potassium counter in ambulatory volunteers.
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