Metabolic Effects of Endotoxin

Wilmore, Douglas W.

Abstract

Endotoxin administration induced the metabolic changes associated with acute infection, including fever, leukocytosis, hypermetabolism, stress hormone release and acute phase protein changes. Also, administration was associated with increased expression of complement receptors on Leukocytes without causing activation of complement. Mitogen stimulated interleukin - 1 & 2 production by circulating monocytes inhibited following endotoxin.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Center for Research Resources (NCRR)
• Type: General Clinical Research Centers Program (M01)
• Project #: 5M01RR002635-05
• Application #: 3907478
• Support Year: 5
• Fiscal Year: 1989

Institution

• Name: Brigham and Women's Hospital
• DUNS #: 071723621
• City: Boston
• State: MA
• Country: United States
• Zip Code: 02115

Publications

Scheuermaier, Karine; Münch, Mirjam; Ronda, Joseph M et al. (2018) Improved cognitive morning performance in healthy older adults following blue-enriched light exposure on the previous evening. Behav Brain Res 348:267-275

Swanson, C; Shea, S A; Wolfe, P et al. (2017) 24-hour profile of serum sclerostin and its association with bone biomarkers in men. Osteoporos Int 28:3205-3213

Juraschek, Stephen P; Woodward, Mark; Sacks, Frank M et al. (2017) Time Course of Change in Blood Pressure From Sodium Reduction and the DASH Diet. Hypertension 70:923-929

Hron, Bridget M; Ebbeling, Cara B; Feldman, Henry A et al. (2017) Hepatic, adipocyte, enteric and pancreatic hormones: response to dietary macronutrient composition and relationship with metabolism. Nutr Metab (Lond) 14:44

Rahman, Shadab A; St Hilaire, Melissa A; Chang, Anne-Marie et al. (2017) Circadian phase resetting by a single short-duration light exposure. JCI Insight 2:e89494

Liu, G; Liang, L; Bray, G A et al. (2017) Thyroid hormones and changes in body weight and metabolic parameters in response to weight loss diets: the POUNDS LOST trial. Int J Obes (Lond) 41:878-886

Nanba, Kazutaka; Vaidya, Anand; Williams, Gordon H et al. (2017) Age-Related Autonomous Aldosteronism. Circulation 136:347-355

Leuze, Christoph; Aswendt, Markus; Ferenczi, Emily et al. (2017) The separate effects of lipids and proteins on brain MRI contrast revealed through tissue clearing. Neuroimage 156:412-422

Gupta, Tina; Connors, Molly; Tan, Jia Wei et al. (2017) Striatin Gene Polymorphic Variants Are Associated With Salt Sensitive Blood Pressure in Normotensives and Hypertensives. Am J Hypertens 31:124-131

Tang, Olive; Miller 3rd, Edgar R; Gelber, Allan C et al. (2017) DASH diet and change in serum uric acid over time. Clin Rheumatol 36:1413-1417