Abstract

The purpose of this study is to investigate a new blood pressure lowering drug. This drug, irbesartan, is a member of a new class of antihypertensive agents which inhibit the renin angiotensin system by blocking the effect of a hormone, angiotensin II. It is hoped that irbesartan, which specifically inhibits the effect of angiotensin will allow blood pressure lowering without contributing to other important side effects, in particular kidney damage to patients with Diabetes Mellitus.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
2M01RR002635-16
Application #
6309373
Study Section
Project Start
1999-12-01
Project End
2000-11-30
Budget Start
Budget End
Support Year
16
Fiscal Year
2000
Total Cost
Indirect Cost

  Institution

Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Scheuermaier, Karine; Münch, Mirjam; Ronda, Joseph M et al. (2018) Improved cognitive morning performance in healthy older adults following blue-enriched light exposure on the previous evening. Behav Brain Res 348:267-275
Juraschek, Stephen P; Woodward, Mark; Sacks, Frank M et al. (2017) Time Course of Change in Blood Pressure From Sodium Reduction and the DASH Diet. Hypertension 70:923-929
Hron, Bridget M; Ebbeling, Cara B; Feldman, Henry A et al. (2017) Hepatic, adipocyte, enteric and pancreatic hormones: response to dietary macronutrient composition and relationship with metabolism. Nutr Metab (Lond) 14:44
Rahman, Shadab A; St Hilaire, Melissa A; Chang, Anne-Marie et al. (2017) Circadian phase resetting by a single short-duration light exposure. JCI Insight 2:e89494
Liu, G; Liang, L; Bray, G A et al. (2017) Thyroid hormones and changes in body weight and metabolic parameters in response to weight loss diets: the POUNDS LOST trial. Int J Obes (Lond) 41:878-886
Nanba, Kazutaka; Vaidya, Anand; Williams, Gordon H et al. (2017) Age-Related Autonomous Aldosteronism. Circulation 136:347-355
Leuze, Christoph; Aswendt, Markus; Ferenczi, Emily et al. (2017) The separate effects of lipids and proteins on brain MRI contrast revealed through tissue clearing. Neuroimage 156:412-422
Gupta, Tina; Connors, Molly; Tan, Jia Wei et al. (2017) Striatin Gene Polymorphic Variants Are Associated With Salt Sensitive Blood Pressure in Normotensives and Hypertensives. Am J Hypertens 31:124-131
Tang, Olive; Miller 3rd, Edgar R; Gelber, Allan C et al. (2017) DASH diet and change in serum uric acid over time. Clin Rheumatol 36:1413-1417
Tan, Jia W; Gupta, Tina; Manosroi, Worapaka et al. (2017) Dysregulated aldosterone secretion in persons of African descent with endothelin-1 gene variants. JCI Insight 2:

Showing the most recent 10 out of 721 publications