This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Periodic occlusion of the upper airway is the most common cause of obstructive sleep apnea (OSA). The strongest risk factor for the development of increased airway collapsibility, and consequent OSA, is obesity. Similarly, weight loss is known to decrease the severity of OSA. To date, it is not clear if there is a dose-response relationship between weight loss and improvement in OSA. The factors involved in weight loss-induced improvements in OSA also remain to be elucidated. The goals of the present protocol are to: 1) determine the association between sleep disordered breathing (SDB) and upper airway physiologic, anthropometric and metabolic parameters; 2) determine the relationship between the degree of weight loss and a) the severity of sleep disordered breathing b) decreases in upper airway collapsibility after weight loss c) other neural, metabolic, anthropometric and physiologic predictors
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