This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Childhood Asthma Study (CAS), a randomized, masked, placebo controlled trial of broad spectrum allergen immunotherapy, identified a group of young adults with moderate to severe asthma who now have persistent lung function deficits. In order to characterize the nature of these functional deficits further, these investigators propose a three part study to examine the lung anatomy and pathophysiology in these subjects including high resolution CT scanning of the airways (HRCT), methacholine challenge tests, and induced sputum (IS) and exhaled condensate studies (EBC). These investigators hypothesize that subjects with persistent lung function deficits will be distinguishable from other cohort member by evidence of increased airway thickening and reduced distensibility on CT scans, increased airway hyperreactivity as expressed by methacholine sensitivity, and increased inflammatory markers on IS and EBC sampling. These studies have important implications for monitoring and prognosis of childhood asthma.
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