This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The primary reason for this study is to determine the general safety and effectiveness of latex allergy shots in latex allergic individuals. Complete avoidance of latex is the only current remedy for those that are allergic and this is often immpossible to achieve without an occupational change which could be economically impacting as well as sometimes unacceptable to health care professionals and others. Furthermore, some studies suggest that moving to a new environment where latex is absent or minimal may not be enough to avoid continuing symptoms or to help with respiratory disease. The need for additional options is therefore very important. There is reason to believe that treatment with regular latex shots similar to traditional allergy shots, may be successful in reducing latex allergy.During this study, we will monitor the effects of the latex shots on the immune systems of our subjects by gathering evidence from several testing methods. Results from blood work, skin testing and challenges of breathing latex particles will be the testing methods we will be using. The results of this study will tell us if this is a practical, effective and safe form of possible treatment for health care workers and people with latex allergy.
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