This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Posttraumatic stress disorder (PTSD) has been shown to be associated with biases in attention to trauma-related material. Likewise, depression has been shown to be associated with memory biases for self-referential, depressive information. That is, PTSD-diagnosed people tend to attend selectively to stimuli that remind them of their trauma, and depressed people tend to remember information that is negative more than other types of information. These biases are thought to have major impact in perpetuating the disorders. However, little is known about the nature of cognitive biases (i.e., preferential processing of certain types of information) when depression and PTSD co-occur, or about the underlying neural activation associated with cognitive biases (i.e, preferential processing of certain types of information) when depression and PTSD co-occur, or about the underlying neural activation associated with cogniving biases. The purpose of this study is to use functional magnetic resonance imaging (fMRI) to examine brain activation associated with cognitive biases in comorbid depression and PTSD.
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