This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Periodic Limb Movement Disorder refers to the condition which repetitive movements of legs and arms occurs during sleep. There is a clear tendency for the prevalence to increase with age. This disorder can occur in young children. This condition disturbs sleep and leads to the inability to sleep, excessive daytime sleepiness or hyperactivity in children. There is no FDA approved medication for PLMD in children. The current medications that are commonly used by pediatric sleep specialists and are recommended by the American Academy of Sleep Medicine for treatment of PLMD in children include Clonazepam, Dopamine receptor agonists and Levadopa. This study is aimed to evaluate the relationship between PLMD and ferritin level in children. In addition, children who have low ferritin level (<50ng/ml) will receive treatment with ferrous sulfate. The response of treatment will be monitored by improvement in the symptoms and actigraphy. The actigraphy is a small watch that children wear on the wrist during sleep and it records the frequency of arm movements during sleep.
Our aim i s to find if simple medication like iron can be used to treat children with periodic limb movement disorder.
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