This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Posterior resin composites are used by 80% of the dentists practicing in the United States. The results of the first clinical trial of posterior composites were published in 1971. Subsequent recalls of the same restorations revealed that the resin composite restorations had poor wear resistance. Early reviews recommended that composite be limited to conservative bicuspid and first molar restorations where esthetics was critical. In spite of improvements in resin composites, material limitations exist which restrict the use of resin composite as a posterior restorative material. Clinically, resin restorations are difficult and require more placement time tkhan a similar sized amalgam restoration. Interproximal contacts are difficult to obtain since composite is a paste material that shrinks during polymerization; two clinical investigations reported weak or defective contacts in 20% of the posterior composite restorations. The development of recurrent caries is a clinical problem with composite resin restorations primarily due to polymerization shrinkage and opening of the restoration gingival cavosurface margins. At present, the best means of diagnosing interproximal recurrent caries is with bitewing radiographs, which records demineralization (the loss of mineral content of the enamel and dentin) as a corresponding decrease in rediographic density. Further developments of composite resin with more wear resistance, reduced polymerization shrinkage and improved adhesive systems with stronger bonds to tooth structure are needed. This study will evaluate the clinical success of a composite with reduced polymerization shrinkage placed in class 1 and class 2 preparations to evaluate whether the composite will pass the certification program established by the American Dental Association.
Specific Aims : 1. To place a composite resin in Class I and Class II cavity preparations, evaluate the resin composite restorations at baseline, 6 months, 1 year, and 18 months for specific criteria (direct and indirect). 2. To evaluate the resin composite restorations for staining, marginal integrity, response to cold, placement time, and proximal contact for 18 months.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR005096-17
Application #
7376333
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2005-12-01
Project End
2006-11-30
Budget Start
2005-12-01
Budget End
2006-11-30
Support Year
17
Fiscal Year
2006
Total Cost
$13,017
Indirect Cost
Name
Tulane University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
053785812
City
New Orleans
State
LA
Country
United States
Zip Code
70118
Allegrezza, Michael J; Rutkowski, Melanie R; Stephen, Tom L et al. (2016) Trametinib Drives T-cell-Dependent Control of KRAS-Mutated Tumors by Inhibiting Pathological Myelopoiesis. Cancer Res 76:6253-6265
Drerup, Justin M; Liu, Yang; Padron, Alvaro S et al. (2015) Immunotherapy for ovarian cancer. Curr Treat Options Oncol 16:317
Chyun, Deborah A; Wackers, Frans J Th; Inzucchi, Silvio E et al. (2015) Autonomic dysfunction independently predicts poor cardiovascular outcomes in asymptomatic individuals with type 2 diabetes in the DIAD study. SAGE Open Med 3:2050312114568476
Wing, Maria R; Yang, Wei; Teal, Valerie et al. (2014) Race modifies the association between adiposity and inflammation in patients with chronic kidney disease: findings from the chronic renal insufficiency cohort study. Obesity (Silver Spring) 22:1359-66
Belzer, Marvin E; Naar-King, Sylvie; Olson, Johanna et al. (2014) The use of cell phone support for non-adherent HIV-infected youth and young adults: an initial randomized and controlled intervention trial. AIDS Behav 18:686-96
Rahman, Mahboob; Xie, Dawei; Feldman, Harold I et al. (2014) Association between chronic kidney disease progression and cardiovascular disease: results from the CRIC Study. Am J Nephrol 40:399-407
Kempen, John H; Sugar, Elizabeth A; Varma, Rohit et al. (2014) Risk of cataract among subjects with acquired immune deficiency syndrome free of ocular opportunistic infections. Ophthalmology 121:2317-24
Ricardo, Ana C; Yang, Wei; Lora, Claudia M et al. (2014) Limited health literacy is associated with low glomerular filtration in the Chronic Renal Insufficiency Cohort (CRIC) study. Clin Nephrol 81:30-7
Kozak, Igor; Vaidya, Vijay; Van Natta, Mark L et al. (2014) The prevalence and incidence of epiretinal membranes in eyes with inactive extramacular CMV retinitis. Invest Ophthalmol Vis Sci 55:4304-12
Wing, Maria R; Devaney, Joseph M; Joffe, Marshall M et al. (2014) DNA methylation profile associated with rapid decline in kidney function: findings from the CRIC study. Nephrol Dial Transplant 29:864-72

Showing the most recent 10 out of 211 publications